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Sleep

Sleep

Complex of rapid-release melatonin and prolonged-release melatonin (Melotime®) to improve your sleep cycles, together with apigenin from chamomile extract.

Informed Sport Informed Sport (Doping Free)
Lab Guaranteed Composition Lab Guaranteed Composition
Main Pollutants Free Main Pollutants Free
Vegan Vegan
Gluten Free Gluten Free
Good Manufacturing Practices Good Manufacturing Practices
Not Genetically Modified Not Genetically Modified
€24,95 EUR
€24,95 EUR
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WHAT ARE MELATONIN AND APIGENIN?

Endogenous melatonin is a naturally produced hormone, synthesized and secreted primarily in the pineal gland.

Melatonin’s main function is to regulate the body’s sleep-wake cycles through interactions with key components of the central nervous system like the hypothalamus and retina. It promotes sleep and inhibits signals that cause wakefulness (1)1. Claustrat B et al. The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 2005 Feb;9(1):11-24.

Apigenin is a bioactive compound extracted from chamomile. Specifically, it is a flavonoid—a type of naturally occurring polyphenol, which plays a key role in the prevention and treatment of a multitude of emerging health issues, highlighting the therapeutic potential of these bioactive compounds (2)2. Salehi B et al. The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019 Mar 15;20(6):1305..

 
 

WHY THIS FORMAT?

The combination of melatonin with extended-release melatonin (Melotime®) allows higher melatonin levels to be achieved both at the onset of sleep, thus improving sleep latency (helping to fall asleep earlier), and during the middle hours of sleep, thus increasing the quality and duration of sleep (3)3. Mun JG et al. A Randomized, Double-Blind, Crossover Study to Investigate the Pharmacokinetics of Extended-Release Melatonin Compared to Immediate-Release Melatonin in Healthy Adults. J Diet Suppl. 2024;21(2):182-194..

The addition of apigenin provides a synergistic effect with the melatonin, improving daytime functioning (2)2. Salehi B et al. The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019 Mar 15;20(6):1305..

 
 

BENEFITS OF MELATONIN SUPPLEMENTATION

According to scientific research, melatonin supplementation provides important benefits associated with various aspects of rest:

– Improvement of sleep latency, quality, and duration (4)4. Ferracioli-Oda E et al. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013 May 17;8(5):e63773..
– Improvement of symptoms associated with jet lag and the adaptation of the sleep-wake cycle when changing time zones (5)5. Janse van Rensburg DCC et al. How to manage travel fatigue and jet lag in athletes? A systematic review of interventions. Br J Sports Med. 2020 Aug;54(16):960-968..

 

BIBLIOGRAPHIC REFERENCES

1. Claustrat B et al. The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 2005 Feb;9(1):11-24

2. Salehi B et al. The Therapeutic Potential of Apigenin. Int J Mol Sci. 2019 Mar 15;20(6):1305.

3. Mun JG et al. A Randomized, Double-Blind, Crossover Study to Investigate the Pharmacokinetics of Extended-Release Melatonin Compared to Immediate-Release Melatonin in Healthy Adults. J Diet Suppl. 2024;21(2):182-194.

4. Ferracioli-Oda E et al. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013 May 17;8(5):e63773.

5. Janse van Rensburg DCC et al. How to manage travel fatigue and jet lag in athletes? A systematic review of interventions. Br J Sports Med. 2020 Aug;54(16):960-968.